Natural killer cell granules converge to avoid collateral damage
نویسندگان
چکیده
منابع مشابه
Natural killer cell granules converge to avoid collateral damage
To clear infection, cytotoxic lymphocytes must destroy target cells while avoiding nonspecific killing of surrounding healthy cells. In this issue, Hsu et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201604136) use live-cell imaging to show that lytic granule convergence protects bystander cells from unintended death by promoting polarized secretion of soluble cytolytic proteins toward ...
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Natural killer (NK) cells are part of the innate immune defense against infection and cancer and are especially useful in combating certain viral pathogens. The utility of NK cells in human health has been underscored by a growing number of persons who are deficient in NK cells and/or their functions. This can be in the context of a broader genetically defined congenital immunodeficiency, of wh...
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Lymphoid neoplasms that are derived from natural killer (NK) cells are uncommon but distinct clinicopathologic disease entities. Three types have been recognized and categorized in the latest World Health Organization classification: extranodal NK cell lymphoma, nasal-type; aggressive NK cell leukemia; and blastic NK cell lymphoma. All NK tumor cells express the NK cell marker CD56, but they la...
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Natural killer (NK) cells, as part of the innate immune system, play a key role in host defense against viral infections. Recent advances have indicated that NK cell activation and function are regulated by the interplay between inhibitory and activating signals. Thus, a better understanding of mechanisms responsible for NK cell activation and function in the control of viral infections will he...
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Background: Although there is convincing data in support of the effectiveness of hyperthermia in tumor therapy, the molecular mechanisms underlying the clinical effects of hyperthermia are still poorly understood. Objective: To investigate natural killer (NK) cell cytotoxicity against heat-treated SW-872 and HeLa tumor cell lines. Methods: NKG2D ligands and HLA class I transcription were examin...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2016
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201612003